Drug Overdose Deaths, U.S., 1999–2016 – NCHS Data Brief No. 294, December 2017

Rates were significantly higher for males than females. For males, the rate increased from 8.2 in 1999 to 26.2 in 2016. For females, the rate increased from 3.9 in 1999 to 13.4 in 2016. National Vital Statistics System Mortality File